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Oct 9, 2020 · A base excess more than +2 mEq/L indicates a metabolic alkalosis. A base excess less than -2 mEq/L indicates a metabolic acidosis. Bicarbonate (HCO 3) Bicarbonate is produced by the kidneys and acts as a buffer to maintain a normal pH. The normal range for bicarbonate is 22 – 26mmol/l.
We learn here that the concept of base excess was developed in 1958 by two Danish clinical biochemist pioneers of blood gas analysis, Poul Astrup and Ole Siggaard-Andersen, on the basis of in vitro human-blood-titration experiments. The aim of their experiments was to develop an index (they called it base excess) to quantify the (non ...
Base excess (BE) was introduced by Siggaard-Andersen in 1960 as an answer to the forty-year-long quest for a reliable, stand-alone marker of metabolic acidosis/alka-losis, independent from co-existing respiratory derange-ments, and able to quantify the severity of the disorder [1]. Previously, several parameters had been examined.
Sep 29, 2023 · Base Excess. It is defined as the amount of acid required to restore a litre of blood to its normal pH at a PaCO2 of 40 mmHg. The base excess increases in metabolic alkalosis and decreases (or becomes more negative) in metabolic acidosis, but its utility in interpreting blood gas results is controversial.
May 21, 2019 · Base Excess (BE) in an ABG. “The base excess is another surrogate marker of metabolic acidosis or alkalosis. A high base excess (> +2mmol/L) indicates that there is a higher than normal amount of HCO 3- in the blood, which may be due to a primary metabolic alkalosis or a compensated respiratory acidosis. A low base excess (< -2mmol/L ...
May 10, 2023 · Thus, base deficit and base excess are used interchangeably. Normal base excess values range from -3 to +3. Therefore, base excess of -5 indicates metabolic acidosis, whereas +5 indicates metabolic alkalosis. Base excess values are frequently used in critically ill patients to analyze acid-base disturbance (9).
Furthermore, in fetal acid-base studies it is of interest to evaluate the correlation of clinical parameters (e.g. the APGAR score and the fetal heart frequency (FHF)) to the spectrum of these four metabolic acid-base variables, the "base excess family" (Table I). Therefore the question must arise: Which base excess should preferably be used?
