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May 14, 2024 · In 2011, Dr. Westlake joined the Laboratory of Cell and Developmental Signaling at the Center for Cancer Research where he studies membrane trafficking pathways important in ciliopathy, diseases linked to primary cilia dysfunction, and cancer. He was awarded tenure from NIH in 2020.
Dr. Westlake’s laboratory uses advanced fluorescence and electron microscopy imaging techniques, biochemical approaches and zebrafish models to investigate membrane trafficking processes regulated by the Rab small GTPase family that are important in development and disease.
Christopher J Westlake. WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the...
Christopher J Westlake's Lab. Institution: National Institutes of Health. Advance your research. Featured research (2) Male infertility‐associated Ccdc108 regulates multiciliogenesis via the...
Jan 15, 2023 · Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella. These organelles play essential roles in motility and signaling on the surface of cells. Cilia are built at the distal ends of centrioles through the formation of an axoneme that is surrounded by the ciliary ….
Feb 22, 2021 · Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short review, we focus on recently reported insight ….
Jul 22, 2019 · Abstract. Serum starvation stimulates cilia growth in cultured cells, yet serum factors associated with ciliogenesis are unknown. Previously, we showed that starvation induces rapid Rab11-dependent vesicular trafficking of Rabin8, a Rab8 guanine-nucleotide exchange factor (GEF), to the mother centriole, leading to Rab8 activation and cilium growth.
