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Due to their rapid metabolism, artemisinin and its derivatives are relatively safe drugs with a relatively high therapeutic index. History Etymology. Artemisinin is an antimalarial lactone derived from qinghao (青蒿, Artemisia annua or sweet wormwood).
Abstract. Artemisinins are derived from extracts of sweet wormwood ( Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis.
Feb 1, 2019 · Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties.
Oct 16, 2020 · Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by ...
Artemisinin, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.
Aug 18, 2021 · Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro.
Jun 6, 2023 · We now know that the unusual structural feature of artemisinin, the 1,2,4-trioxane ring, is the basis for the unique antimalarial action of the drug. It is the endoperoxide linkage in the ring which 'triggers' artemisinin to 'explode' - but only in the vicinity of the Plasmodium parasite.
