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Learn how sodium-channel blockers affect cardiac action potentials, conduction velocity, and arrhythmias. Compare the subclasses of Class I drugs based on their effects on phase 0, phase 3, and automaticity.
Sodium channel blockers are drugs which impair the conduction of sodium ions (Na +) through sodium channels.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Apr 28, 2022 · Antiarrhythmics are medications that prevent and treat abnormal heart rhythms. Class I drugs are sodium channel blockers that slow electrical impulses in the heart muscle. Learn more about the benefits, risks and interactions of antiarrhythmics.
Brittany Norton, MFA, Sam Gillespie, BSc, Yifan Xiao, MD. Antiarrhythmic drugs help control arrhythmias or abnormal heartbeats. There are four main groups of antiarrhythmic medications: class I, sodium-channel blockers; class II, beta-blockers; class III, potassium-channel blockers; class IV, calcium-channel blockers; and miscellaneous ...
Mar 2, 2024 · Sodium channel blocker toxicity is a critical aspect of clinical care given the widespread use of medications such as Vaughn Williams Class 1 antiarrhythmics, local anesthetics, and neuropathic pain treatments like tricyclic antidepressants (TCAs), anticonvulsants, and cocaine.
The term “sodium channel blockers” covers a wide range of naturally occurring and synthetic compounds that block the ion permeation through sodium-selective ion channels, large transmembrane proteins that control rapid membrane depolarization in electrically excitable cells.
