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Jun 30, 2020 · There are many types of morphological patterns that necrosis can present itself. These are coagulative, liquefactive, caseous, gangrenous which can be dry or wet, fat and fibrinoid. Necrosis can start from a process called “oncosis”. Oncosis comes from the Greek origin ónkos, meaning swelling.
Caseous necrosis or caseous degeneration (/ ˈ k eɪ s i ə s /) is a unique form of cell death in which the tissue maintains a cheese-like appearance. Unlike with coagulative necrosis, tissue structure is destroyed. Caseous necrosis is enclosed within a granuloma. Caseous necrosis is most notably associated with tuberculoma.
M. tuberculosis cannot grow outside of the lung parenchyma. M. tuberculosis first infects type 1 pneumocytes and replicates within the cytoplasm of the pneumocyte. Resident macrophages within the lungs are the primary cell that is infected, upon initial infection by M. tuberculosis.
Feb 10, 2017 · Granulomatous inflammation is a histologic pattern of tissue reaction which appears following cell injury. Granulomatous inflammation is caused by a variety of conditions including infection, autoimmune, toxic, allergic, drug, and neoplastic conditions.
Gross: White, soft, cheesy-looking (“caseous”) material; Micro: fragmented cells and debris surrounded by a collar of lymphocytes and macrophages (granuloma)
Caseous Necrosis. Histologically, caseous necrosis appears as eosinophilic, granular, acellular material characterized by complete loss of tissue structure, in contrast to coagulative necrosis, which preserves some ghost tissue outline. From: Practical Hepatic Pathology, 2011
Caseous necrosis Granulomas are aggregates of epithelioid macrophages and giant cell macrophages, often surrounded by lymphocytes. Granulomas are found as a response to foreign bodies, in some autoimmune diseases, and in mycobacterial infection (e.g. M.tuberculosis).
