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Pyrexia of unknown origin (PUO), also known as fever of unknown origin (FUO), is a grouping of many unrelated medical conditions that share the feature of persistent unexplained fever despite basic investigation.
Oct 15, 2010 · Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits. Common causes are infections, neoplasms, and connective tissue disorders.
Fever of unknown origin (FUO) refers to a condition in which the patient has an elevated temperature but, despite investigations by one or more qualified physicians, no explanation is found. If the cause is found it is usually a diagnosis of exclusion, eliminating all possibilities until only the correct explanation remains.
The syndrome of pyrexia of unknown origin (PUO) was first defined in 1961 but remains a clinical challenge for many physicians. Different subgroups with PUO have been suggested, each requiring different investigative strategies: classical, nosocomial, neutropenic and HIV-related.
Apr 10, 2017 · Key features of fever of unknown origin (FUO), also known as pyrexia of unknown origin (PUO), are as follows: Unexplained fevers are worrisome to patients and clinicians, but most...
Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations. 2...
What causes pyrexia of unknown origin? Pyrexia of unknown origin has a wide differential diagno‑ sis. The most frequently encountered underlying causes of the pyrexia are listed in box 2. Broadly speaking, the three most common causes are infection, neoplasia, and connective tissue disease. Many prospective and retro‑
Nov 28, 2023 · Clinicians commonly refer to a febrile illness without an initially obvious etiology as fever of unknown origin (FUO). However, most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.
Fever of unknown origin (FUO) is body temperature ≥ 38.3° C (≥ 101° F) rectally that does not result from transient and self-limited illness, rapidly fatal illness, or disorders with clear-cut localizing symptoms or signs or with abnormalities on common tests such as chest x-ray, urinalysis, or blood cultures.
Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961. FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or higher with a minimum duration of three weeks without an established diagnosis after an intensive one-week investigation in the hospital.
