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  1. 7 Jul 2024 · Wake-up strokes occur when a person goes to bed feeling normal and wakes up with symptoms of a stroke. The key difference between wake-up strokes and other types of stroke is that the time of onset is unknown. This can delay emergency medical treatment and exclude wake-up stroke survivors from typical stroke treatments.

  2. 26 Mac 2014 · Patients waking-up with symptoms of stroke represent a specific subgroup of stroke patients. In general, stroke is the second most common single cause of death and the most frequent cause of permanent disability in industrialized countries.

  3. Wake-up stroke, defined as the situation where a patient awakens with stroke symptoms that were not present prior to falling asleep, represents roughly 1 in 5 acute ischemic strokes and remains a therapeutic dilemma.

  4. 4 Ogo 2015 · Patients waking up with stroke symptoms represent a distinct but underprivileged subgroup of patients with stroke. Because in wake-up stroke the time of symptom onset is unknown these patients are a challenge to acute stroke treatment.

  5. 16 Mei 2018 · WAKE-UP was an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled clinical trial involving patients with an unknown time of onset of stroke. All the...

  6. 6 Dis 2023 · A wake-up stroke occurs when you go to sleep healthy, without any signs of a stroke, and wake up with stroke symptoms. When someone has a wake-up stroke, it’s difficult to know...

  7. Wake-up strokes (WUS) are strokes with unknown exact time of onset as they are noted on awakening by the patients. They represent 20% of all ischemic strokes.

  8. 4 Sep 2008 · Detection of neurological symptoms of stroke on awakening (wake-up stroke) is a relatively common situation. A statewide survey of patients admitted with stroke into hospitals in California noted that 8% of the cases had symptoms on awakening. 1 Other groups have described higher frequencies.

  9. 10 Jan 2020 · The WAKE UP [41••] trial was a randomized, double-blind, placebo-controlled trial that enrolled stroke patients who either awoke with stroke symptoms or could not identify the time of symptom onset. Patients were imaged with MRI DWI and FLAIR sequencing and those with an acute stroke on DWI sequences but without any visible abnormality on ...

  10. 7 Nov 2013 · Introduction. Approximately 25% of patients with ischemic stroke awake with neurological deficits. In these wake-up strokes (WUS), the onset of symptoms is defined as “time last-seen well” (TLSW).