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Jul 20, 2020 · Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.
This continual resorption and re-deposition of bone mineral, or bone remodelling, is intimately tied to the pathophysiology of osteoporosis. Understanding how bone remodelling is regulated is the key to the effective prevention and treatment of osteoporosis.
Jun 21, 2020 · However, osteoporosis is now classified as a primary disorder of the skeleton related to profound metabolic changes not only in bone but also related to changes in whole body homeostasis. Significant progress has been made in both defining this disorder and in understanding its complex pathogenesis.
Aug 4, 2023 · Osteoporosis is defined as low bone mineral density caused by altered bone microstructure, ultimately predisposing patients to low-impact, fragility fractures. Osteoporotic fractures lead to a significant decrease in quality of life, with increased morbidity, mortality, and disability.
Jan 8, 2024 · Osteoporosis, a chronic, progressive disease of multifactorial etiology (see Etiology), is the most common metabolic bone disease in the United States. It has been most frequently recognized in...
Pathophysiology of Osteoporosis. calcitonin, estrogen, vitamin D, various cytokines, and other local factors such as prostaglandins. Peak bone mass in men and women occurs around age 30. Men have higher bone mass than women. (Previous data suggesting people with African ancestry achieve higher peak bone mass are currently being questioned.)
Feb 24, 2024 · Osteoporosis causes bones to become weak and brittle — so brittle that a fall or even mild stresses such as bending over or coughing can cause a break. Osteoporosis-related breaks most commonly occur in the hip, wrist or spine. Bone is living tissue that is constantly being broken down and replaced.
