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Jun 11, 2024 · However, the mechanism underlying TTX accumulation in flatworms remains unclear. Previous studies have been limited to identifying the distribution of TTX in multiple organs, such as the digestive organs, genital parts, and the remaining tissues of flatworms.
Jun 15, 2024 · Abstract. An accumulation of reactive oxygen species (ROS) in cardiomyocytes can induce pro-arrhythmogenic late Na + currents by removing the inactivation of voltage-gated Na + channels including the tetrodotoxin (TTX)-resistant cardiac α-subunit Nav1.5 as well as TTX-sensitive α-subunits like Nav1.2 and Nav1.3.
3 days ago · Adenosine is arguably one of the most important neuromodulators in the brain. Acting via the inhibitory A1 receptors, adenosine modulates neuronal excitability, neural circuit activity and ...
Jun 26, 2024 · An underlying mechanism by which lead is able to cause harm is its ability to be transported by calcium ATPase pumps across the BBB, allowing for direct contact with the fragile cells within the central nervous system.
1 day ago · Back in 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain's outer cortical cells that produces a novel 'graded' signal all on its own, one that could provide individual neurons with another way to carry out their logical functions.
4 days ago · The lateral septum (LS) is composed of heterogeneous cell types that are important for various motivated behaviors. However, the transcriptional profiles, spatial arrangement, function, and connectivity of these cell types have not been systematically studied. Using single-nucleus RNA sequencing, we delineated diverse genetically defined cell ...
Jun 25, 2024 · This unit describes essential procedures to record the activity of and the effects of pharmacological manipulation upon tetrodotoxin-resistant (TTXr) sodium channels. Readers are guided through the process of assembling a functional |patch-clamp| electrophysiology apparatus and construction of softw …
