Search results
David Snodin. For decades, regulators have grappled with different approaches to address the issue of control of impurities. Safety-based limits, such as permissible daily exposure (PDE ...
May 21, 2013 · Dr. David Snodin studied Chemistry at Imperial College, London, moving to Bristol University to undertake research for a Ph.D. in Organic Chemistry. He later obtained an M.Sc. in Toxicology at the University of Surrey.
Xiphora Biopharma Consulting. 2010 - Present 14 years.
May 26, 2015 · david snodin. Principal at Xiphora Biopharma Consulting. Published May 26, 2015. + Follow. Mutagenic Alkyl-Sulfonate Impurities in Sulfonic Acid Salts: Reviewing the Evidence and Challenging...
ABSTRACT: Alkyl sulfonates are direct-acting bacterial mutagens and are almost universally regarded by regulatory authorities to be potential impurities in drug substances presented as sulfonic...
Feb 5, 2024 · David Snodin The TTC (Threshold of Toxicological Concern; set at 1.5 μg/day for pharmaceuticals) defines an acceptable patient intake for any unstudied chemical posing a negligible risk of ...
Abstract. The cancer TTC (Threshold of Toxicological Concern) concept is currently employed as an aid to risk assessment of potentially mutagenic impurities (PMIs) in food, cosmetics and other sectors. Within the pharmaceutical industry the use of one default cancer TTC limit of 1.5 μg/day for PMIs is being increasingly questioned.
