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  1. IL-1 and IL-6 play a major part in the pathogenesis of fever. Lymphokines are cytokines that are secreted by lymphocytes to regulate the immune response. Important lymphokines are IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-14 and TNF-gamma.

  2. 4 Sep 2023 · Fever occurs when either endogenous or exogenous pyrogens cause an elevation in the body's thermoregulatory set-point. In hyperthermia, the set-point is unaltered, and the body temperature becomes elevated in an uncontrolled fashion due to exogenous heat exposure or endogenous heat production.

  3. Pathophysiology of Fever. Body temperature is determined by the balance between heat production by tissues, particularly the liver and muscles, and heat loss from the periphery.

  4. 23 Nov 2022 · Definitions of normal body temperature, the pathophysiology of fever, the role of cytokines, and the treatment of fever in adults will be reviewed here. Fever of unknown origin in adults, drug fever, and the treatment of fever in infants and children are discussed separately.

  5. 14 Jul 2016 · This narrative review is part of a series that will outline the pathophysiology of pyrogenic and non-pyrogenic fever, concentrating primarily on the pathophysiology of non-septic causes. Keywords: Hyperthermia, Fever, Organ failure, Physiopathology, Heatstroke

  6. 2 Jan 2019 · Although acute-phase response is closely associated with fever, CRP levels can be normal in viral infections and high in diseases without fever (e.g. tumours). Syntheses of albumin and transferrin and the concentration of iron and zinc decrease, while copper concentration increases.

  7. 4 Sep 2023 · Introduction. Issues of Concern. Cellular Level. Organ Systems Involved. Function. Mechanism. Related Testing. Pathophysiology. Clinical Significance. Review Questions.