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Jul 4, 2023 · Hereditary spherocytosis (HS) is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane and classifies as a type of congenital hemolytic anemia.
Hereditary spherocytosis ( HS) is a congenital hemolytic disorder wherein a genetic mutation coding for a structural membrane protein phenotype causes the red blood cells to be sphere-shaped ( spherocytosis ), rather than the normal biconcave disk shape.
May 19, 2022 · In hereditary spherocytosis, your red blood cells lose their characteristic disk-like shape, becoming round, or spherical cells (spherocytes), that can’t function like normal red blood cells.
Hereditary spherocytosis is a condition characterized by hemolytic anemia (when red blood cells are destroyed earlier than normal). Symptoms can range from mild to severe and may include pale skin, fatigue, anemia, jaundice, gallstones, and/or enlargement of the spleen.
Jun 20, 2023 · Hereditary spherocytosis is an inherited abnormality of the red blood cell, caused by defects in structural membrane proteins. It is the most common form of inherited haemolytic anaemia in the US and northern Europe.
Jan 1, 2024 · Hereditary spherocytosis (HS) is an inherited condition of red blood cells. The disease can be mild and go unrecognised in some people. In others there may be severe anaemia requiring regular blood transfusions. Some people with hereditary spherocytosis may be offered surgery to remove their spleen.
Oct 24, 2021 · Hereditary spherocytosis (HS), a commonly encountered hereditary hemolytic disease, is mostly inherited in an autosomal‐dominant manner. The clinical manifestations in patients with HS show obvious heterogeneity.
Hereditary spherocytosis is a condition that affects red blood cells. People with this condition typically experience a shortage of red blood cells ( anemia ), yellowing of the eyes and skin (jaundice), and an enlarged spleen (splenomegaly).
Oct 25, 2023 · INTRODUCTION. Although relatively rare, hereditary spherocytosis (HS) is the most common cause of hemolytic anemia due to a red cell membrane defect. It is a result of heterogeneous alterations in one of five genes that encode red blood cell (RBC) membrane proteins involved in vertical associations that link the membrane cytoskeleton to the ...
Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis. ORPHA:822. Classification level: Disorder. Synonym (s): Minkowski-Chauffard disease. Prevalence: 1-5 / 10 000.
