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Jan 5, 2024 · What is fidaxomicin? Fidaxomicin is a macrolide antibiotic that fights bacteria. Fidaxomicin is used to treat diarrhea caused by infection with Clostridium difficile. Fidaxomicin is for use in adults and children at least 6 months old.
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins. It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis .
May 12, 2013 · Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by Clostridioides (formerly Clostridium) difficile in adult and pediatric patients over the age of 6 months. 10 Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation. 8 Because fidaxomicin contains an 18-membered lactone ring in ...
Mechanism of Action: Fidaxomicin is a macrocyclic antibiotic. It inhibits Clostridium difficile through inhibition of RNA synthesis by binding to RNA polymerase sigma subunit. Pharmacokinetics:
Fidaxomicin is used to treat diarrhea caused by Clostridium difficile (C. difficile; a type of bacteria that may cause severe or life-threatening diarrhea) in adults and children 6 months of age and older. Fidaxomicin is in a class of medications called macrolide antibiotics. It works by killing bacteria in the intestines.
Feb 19, 2024 · Dificid (fidaxomicin) is an antibiotic used to treat diarrhea caused by infection with Clostridium difficile. Includes Dificid side effects, interactions and indications.
Fidaxomicin is used to treat Clostridium difficile-associated diarrhea (CDAD). Fidaxomicin belongs to the class of medicines known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
Fidaxomicin is inactive against Gram-negative organisms and yeasts (Candida). Fidaxomicin has potential advantages over other drugs used to treat CDI and a number of properties that appear ideally suited to the treatment of CDI [Johnson, 2007]. Unlike vancomycin which is bacteriostatic, fidaxomicin is bactericidal.
View fidaxomicin information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, directions for administration and drug action.
Oct 6, 2022 · Fidaxomicin, administered orally, is the first member of the macrocycles class of antibiotics, and it shows bactericidal activity against C. difficile [13,14]. In addition, fidaxomicin has negligible activity against other bacteria constituting the gut microbiota [15,16].
