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  1. www.cliffsnotes.com › study-notes › 15817404Short revision (docx) - CliffsNotes

    4 days ago · Involvement in Disease: Translocations can disrupt gene function and lead to disease, particularly if they involve important regulatory or coding regions. Example Disease: Chronic Myelogenous Leukemia (CML): Often caused by a translocation between chromosomes 9 and 22, creating the Philadelphia chromosome.

  2. quizlet.com › 395605662 › chapter-18-oncology-flash-cardsChapter 18- Oncology Flashcards | Quizlet

    4 days ago · a. Cancer cells often divide more rapidly than normal cells. b. Cancerous cells are arranged in an orderly fashion. c. The p53 gene is an abnormal gene found only in cancer cells. The Philadelphia chromosome appears in __________. chronic myelogenous leukemia.

  3. www.drugpatentwatch.com › p › tradenameSPRYCEL Market Exclusivity Period (MEP). When do the SPRYCEL...

    3 days ago · treatment of pediatric patients with philadelphia chromosome-positive (ph+) chronic myeloid leukemia (cml) in chronic phase exclusivity expiration: ⤷ sign up INDICATED FOR THE TREATMENT OF PEDIATRIC PATIENTS 1 YEAR OF AGE AND OLDER WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) IN COMBINATION WITH ...

  4. amjcaserep.com › abstract › indexLong-Term Remission in T315I+ Relapsed Philadelphia Chromosome...

    4 days ago · BACKGROUND Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in adults has a poor prognosis with conventional chemotherapy. Treatment with tyrosine kinase inhibitors (TKIs) followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved clinical outcomes; however, the relapse rate is still high.

  5. www.nature.com › leu › research-articlesResearch articles | Leukemia - Nature

    2 days ago · Philadelphia chromosome-positive (Ph+) lymphoid blast crisis (BC), emanating from chronic myeloid leukemia (CML), is a fatal disease with limited treatment options. Asciminib (ABL001) is a novel ...

  6. checkrare.com › 2024-orphan-drugs-pdufa-dates-and-fda-approvals2024 Orphan Drugs: PDUFA Dates and FDA Approvals

    1 day ago · CD19-positive Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia: Amgen: APPROVED: 6.16.2024: Imetelstat: Lower risk myelodysplastic syndromes (MDS) Geron Corporation: APPROVED: 6.21.2024: ELEVIDYS (delandistrogene moxeparvovec-rokl) Duchenne muscular dystrophy (DMD) Sarepta Therapeutics: APPROVED: 6.21.2024

  7. www.biorxiv.org › content › 10circPCMTD1: A protein-coding circular RNA that regulates DNA ......

    4 days ago · In in vivo experiments, circPCMTD1 targeting prolonged the survival of mice engrafted with leukemic blasts harboring the Philadelphia chromosome. Mechanistically, we found that circPCMTD1 was enriched in the cytoplasm and associated with the ribosomes of the leukemic cells.