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  1. May 23, 2021 · This happens during the Define stage when we organise, interpret, and make sense of the data we have gathered to create a problem statement. Although analysis takes place during the Empathise stage and synthesis takes place during the Define stage, they do not only happen in the distinct stages of Design Thinking.

  2. 2 days ago · The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century. The scientific method involves careful observation coupled with rigorous scepticism, because cognitive assumptions can distort the interpretation of the observation.

  3. 2 days ago · Preadolescence may also be defined as the period from 10 to 13 years. The point at which a child becomes an adolescent is defined by the major onset of puberty. However, in some individuals (particularly females), puberty begins in the preadolescence years.

  4. 2 days ago · Background The aim of this study was to assess homologous recombination deficiency (HRD) status and its correlation with carboplatin treatment response in early triple-negative breast cancer (TNBC) patients. Methods Tumor tissues from 225 consecutive TNBC patients were evaluated with an HRD panel and homologous recombination-related (HRR) gene expression data. HRD positivity was defined as a ...

  5. 2 days ago · The water–cement ratio significantly affects the mechanical properties of concrete with changes in porosity serving as a key indicator of these properties, which are correlated with the ultrasonic wave velocity and energy evolution. This study conducts uniaxial compression tests on concrete with varying water–cement ratios, analyzing energy evolution and ultrasonic wave velocity variations ...

  6. 1 day ago · Significant upregulation of miR-199b-5p was observed in T1DM, which was significantly downregulated by metformin. miR-199b-5p correlated positively with vascular endothelial growth factor-D and c-reactive protein (CRP: nonsignificant). ROC analysis determined miR-199b-5p to define subclinical CVD by discriminating between HCs and T1DM individuals.

  7. 2 days ago · The Paris Agreement (or Paris Accords, Paris Climate Accords) is an international treaty on climate change that was signed in 2016. The treaty covers climate change mitigation, adaptation, and finance.