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This discussion does not include some methods, such as analysis of base excess or Stewart’s strong ion difference. A summary of these techniques can be found in some of the suggested articles. It is unclear whether these alternate methods offer clinically important advantages over the presented approach, which is based on the “anion gap.”
Dec 20, 2017 · Keywords: base excess, anion gap, lactate, septic shock Introduction Septic shock is a syndrome of pathologic, physiologic, and biochemical disturbances caused by infection, and it is a major public health concern worldwide. 1 , 2 The overall mortality rate and cost of treatment are high.
Jan 1, 2019 · The anion gap (AG) and the strong ion gap (SIG) exploit the principle of electroneutrality to quantify the net balance of unmeasured ions in plasma. The AG should be corrected for abnormalities in plasma albumin and phosphate concentrations. The AG and SIG can be used to narrow the differential diagnosis of acid-base disorders, and an increased ...
Dec 1, 2017 · Methods The relationships between SIG, lactate, anion gap (AG), anion gap albumin-corrected (AG-corrected), base excess or strong ion difference-effective (SIDe), all obtained within the first ...
Nov 3, 2020 · Normal Anion Gap Metabolic Acidosis. if hyponatraemia is present the plasma [Cl-] may be normal despite the presence of a normal anion gap acidosis -> this could be considered a ‘relative hyperchloraemia’. secretions into the large and small bowel are mostly alkaline with a bicarbonate level higher than that in plasma.
Sep 25, 2018 · The anion gap (AG), the difference between unmeasured plasma anions and the unmeasured plasma cations, 8 is an additional diagnostic tool to assess the metabolic components of the acid–base equilibrium. Albumin and phosphate, one of the circulatory proteins, mainly account for the AG under normal conditions.
If the AG is elevated, there is an anion gap metabolic acidosis present. Proceed to step 2b. If the AG not elevated, there is not an anion gap metabolic acidosis present. Proceed to step 3. Step 2b: Calculate and Interpret the Excess Anion Gap. If there is an anion gap, determine whether the excess in AG fully explains the drop in bicarbonate.
