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    castrate
    /kaˈstreɪt/

    verb

    • 1. remove the testicles of (a male animal or man).

    noun

    • 1. a man or male animal whose testicles have been removed: "young human castrates, or eunuchs"

    More definitions, origin and scrabble points

  2. 4 days ago · Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer ... Each regulon is defined as a TF and its target genes. A regulon’s ...

  3. 4 days ago · A neuter procedure is the surgical removal of a male cat’s testicles. Reading that definition might make you cringe. You may even question if the procedure is worth it. It’s not something you or...

  4. 4 days ago · This activity is intended for oncologists, urologists and radiation oncologists involved in the treatment and management of prostate cancer. The goal of this activity is to review key therapies and common challenges in patients with castration-resistant prostate cancer (CRPC).

  5. 20 hours ago · Background Neuroendocrine prostate cancer (NEPC), a lethal subset of prostate cancer (PCa), is characterized by loss of AR signaling and resistance to AR-targeted therapy. While it is well reported that second-generation AR blockers induce neuroendocrine (NE) trans-differentiation of castration-resistant prostate cancer (CRPC) to promote the occurrence of NEPC, and pluripotent transcription ...

  6. 4 days ago · verb. remove the testicles of a male animal. synonyms: castrate, demasculinise, emasculate. see more. Cite this entry. Style: MLA. "Demasculinize." Vocabulary.com Dictionary, Vocabulary.com, https://www.vocabulary.com/dictionary/demasculinize. Accessed 07 Jul. 2024. Copy citation. Examples from books and articles. loading examples... Word Family.

  7. 1 day ago · Introduction: Sarcopenia is a predictor of clinical outcomes in men with metastatic castrate-resistant prostate cancer (mCRPC); however, correlates and predictors of sarcopenia are poorly understood in this population. The aim of this study was to examine correlates and predictors of sarcopenia in men with mCRPC prior to treatment.

  8. 3 days ago · CRPC to me is really simply defined: You have a castrate level of testosterone and disease progression. Disease progression can be measured either by biochemical parameters, such as PSA; radiographic parameters, such as bone scan; or clinical parameters, such as pain.

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