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3 days ago · Adenosine is arguably one of the most important neuromodulators in the brain. Acting via the inhibitory A1 receptors, adenosine modulates neuronal excitability, neural circuit activity and ...
2 days ago · The mIPSCs were recorded in the BLA in voltage-clamp mode at -70 mV. Glutamate receptor blockers 6, 7-dinitroquinoline, 2, 3-dione (CNQX, 20 µM), tetrodotoxin (TTX, 1 µM) and DL-2-amino-5 phosphonovalerate (AP-5, 30 µM) were added to extracellular solution during recording.
4 days ago · The lateral septum (LS) is composed of heterogeneous cell types that are important for various motivated behaviors. However, the transcriptional profiles, spatial arrangement, function, and connectivity of these cell types have not been systematically studied. Using single-nucleus RNA sequencing, we delineated diverse genetically defined cell ...
2 days ago · Although 6-ND also potentiates catecholamine-induced contractions in the RIEVD , the mechanism involved is different from that of 6-CYD, since the potentiation induced by 6-ND was abolished by pre-incubation with tetrodotoxin and was not selective at lower concentrations for EFS- and noradrenaline-induced contractions . In addition, the ...
1 day ago · Back in 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain's outer cortical cells that produces a novel 'graded' signal all on its own, one that could provide individual neurons with another way to carry out their logical functions.
3 days ago · The mechanism of action of tetrodotoxin is both fascinating and highly specific. Sodium channels are crucial for the generation of action potentials in neurons, which are essential for nerve signal transmission. Tetrodotoxin exerts its effects by binding to these channels with high affinity, thereby blocking the influx of sodium ions.
3 days ago · The mechanism of action of the drug is to inhibit the presynaptic reuptake of serotonin from the synaptic cleft (SSRI). Norepinephrine and dopamine transport are also blocked to a small extent. Sertraline slightly binds to adrenergic, histamine, muscarinic, dopaminergic, serotonergic, benzodiazepine, and GABA receptors.
