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Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane.
Adult: For the treatment of cases with regular uterine contractions (>30 seconds at a rate of ≥4 contractions per 30 minutes), cervical dilation of 1-3 cm (0-3 cm for nulliparas) and effacement of ≥50%, gestational age of 24-33 completed weeks, and normal fetal heart rate: Initially, 6.75 mg as a bolus inj of a solution containing 6.75 mg/0 ...
May 11, 2015 · Atosiban reduces the frequency of uterine contractions to delay pre-term birth in adult females and induces uterine quiescence 5, 1. Mechanism of action. Atosiban is a synthetic peptide oxytocin antagonist 5, 1. It resembles oxytocin with has modifications at the 1, 2, 4, and 8 positions.
The active substance in Tractocile, atosiban, is an antagonist of the natural hormone oxytocin. This means that atosiban blocks the action of oxytocin. Oxytocin is the hormone involved in starting contractions of the womb.
Sep 5, 2023 · Tocolysis may enable pregnancy prolongation, at least over the short term, and thus provide time for further in utero maturation and interventions that may improve infant outcome. This topic will discuss the use of tocolytic drugs for inhibition of acute preterm labor.
Atosiban SUN is a medicine that contains the active substance atosiban. It is used to delay birth in adult women who are 24 to 33 weeks pregnant, when they show signs that they may give birth pre-term (prematurely).
Tractocile is a solution for injection and a concentrate that is made up into a solution for infusion (drip into a vein). Both contain the active substance atosiban (7.5 mg per millilitre).
Oct 2, 2019 · Atosiban is a uterine-specific, mixed vasopressin V1-a and oxytocin-receptor antagonist, that is registered for tocolysis in imminent premature birth. It also inhibits uterine contractility in nonpregnant women. Thus, Atosiban may decrease uterine contractions and promote uterine receptivity in patients undergoing embryo transfer.
View atosiban information, including dose, uses, side-effects, contra-indications, monitoring requirements and directions for administration.
Atosiban SUN is a medicine that contains the active substance atosiban. It is used to delay birth in adult women who are 24 to 33 weeks pregnant, when they show signs that they may give birth pre-term (prematurely).
