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  1. Brimstone is a passive item. Isaac's tears are replaced with a charged blood laser beam. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. The laser deals damage equal to Isaac's damage and deals damage each tick.

  2. Welcome back everybody to the long awaited sequel to my most popular video of all time, the BEST SYNERGIES for Brimstone in the Binding of Isaac REPENTANCE! ...

  3. Apr 18, 2021 · This video will quickly showcase most of the new synergies with Brimstone added in The Binding of Isaac: Repentance. Let me know in the comments if I missed ...

  4. Jul 17, 2021 · ULTIMATE BRIMSTONE! - The Binding Of Isaac: Repentance #112 BECOME A MOSH PIT MVP! / @sinvicta PATREON CAMPAIGN! / sinvicta REPENTANCE IS HERE! The long-awaited expansion to the hugely popular...

  5. This is indeed re-added again in repentance. Brimstone and Dr. fetus used to not synergize until afterbirth and now they don't interact again in repentance.

  6. Sep 18, 2021 · With Tiny Planet and Brimstone, Isaac will shoot a laser that forms a ring around his body. This is cool enough, but Lost Contact ties this build up. Lost Contact destroys enemy projectiles in contact with Isaac's tears.

  7. Documenting the different combinations of items available through the Bag of Crafting item in The Binding of Isaac: Repentance.