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Amantadine is a weak dopamine agonist with antiparkinsonian effects. It is used for Parkinson's disease, post-herpetic neuralgia, influenza and fatigue in multiple sclerosis, but has many side-effects and contraindications.
- Parkinson's disease | Treatment summaries | BNF | NICE
If dyskinesia is not adequately managed by modifying...
- Parkinson's disease | Treatment summaries | BNF | NICE
Aug 15, 2023 · Amantadine is used to treat Parkinson's disease and "Parkinson-like" symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs. Amantadine is also used to treat or prevent influenza A in adults and children.
Amantadine may decrease the excretion rate of Warfarin which could result in a higher serum level. Yellow fever vaccine The therapeutic efficacy of Yellow fever vaccine can be decreased when used in combination with Amantadine.
Apr 24, 2023 · Amantadine is a first-line agent for fatigue in multiple sclerosis. Amantadine may be useful in restless leg syndrome. However, data is limited to a small clinical trial. Amantadine has also been used in traumatic brain injuries. Initial studies had suggested that it may promote functional recovery.
Amantadine hydrochloride is a second-line option for adjuvant therapy in Parkinson's disease patients with dyskinesia or motor fluctuations. It can also be used to treat daytime sleepiness and sudden onset of sleep.
Amantadine is a weak dopamine agonist with modest antiparkinsonian effects and may be used for dyskinesias in advanced disease. NICE NG71 states “If dyskinesia is not adequately managed by modifying existing therapy, consider amantadine”. AREAS OF RESPONSIBILITY FOR SHARED CARE.
Amantadine is the only glutamate antagonist drug that is prescribed to treat Parkinson’s. It is an unbranded form of Parkinson’s medication, which comes in the form of capsules and syrup. Find out more about Amantadine and its side effects.
