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Southeast Asian ovalocytosis is a blood disorder that is similar to, but distinct from hereditary elliptocytosis. It is common in some communities in Malaysia and Papua New Guinea, as it confers some resistance to cerebral Falciparum Malaria.
Southeast Asian ovalocytosis (SAO) is an autosomal dominant inherited red blood cell (RBC) membrane disorder caused by the heterozygous deletion of codons 400–408 in SLC4A1/band 3/anion exchanger 1 (AE1). 1 This deletion leads to misfolding of the protein, creating an inactive anion-transporter and altering the mechanical stability of the RBC.
Southeast Asian ovalocytosis (SAO) is a rare hereditary red cell membrane defect characterized by the presence of oval-shaped erythrocytes and with most patients being asymptomatic or occasionally manifesting with mild symptoms such as pallor, jaundice, anemia and gallstones.
Southeast Asian (SEA) ovalocytosis is a largely benign condition characterised by stomatoctes in the peripheral blood. The vast majority of patients are asymptomatic, although a small minority will have a mild anaemia.
Dec 1, 2017 · Southeast asian ovalocytosis (SAO) is characterized by macro-ovalocytes and ovalo-stomatocytes on blood smear. SAO is common in Malaisia and Papua-New-Guinea where upwards to 40 per cent of the population is affected in some coastal region.
Southeast Asian ovalocytosis (SAO) is a common inherited red blood cell polymorphism in Southeast Asian and Melanesian populations, coinciding with areas of malaria endemicity.
Nov 15, 2003 · Southeast Asian ovalocytosis (SAO) is a red blood cell abnormality common in malaria-endemic regions and caused by a 27 nt deletion of the band 3 protein gene.
Southeast Asian ovalocytosis is a hereditary red blood cell disorder that is widespread in certain ethnic groups of Malaysia, Papua New Guinea, the Philippines, and Indonesia. Ovalocytic erythrocytes are rigid and exhibit reduced expression of many erythrocyte antigens.
Southeast Asian ovalocytosis (SAO) is a red blood cell abnormality common in malaria-endemic regions and caused by a 27 nt deletion of the band 3 protein gene.
Nov 12, 2020 · Homozygous Southeast Asian Ovalocytosis in five live-born neonates. Haematologica. 2020 Nov 12;Online ahead of print. doi: 10.3324/haematol.2020.268581. Authors.
