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Fibronectin is a dimeric protein that binds to integrins and other matrix components. It has two isoforms: plasma fibronectin and cellular fibronectin, which are involved in cell adhesion, migration, and differentiation.
Oct 2, 2024 · FN1 is a protein coding gene that encodes fibronectin, a glycoprotein involved in cell adhesion and migration. FN1 is associated with several diseases, has multiple transcript variants, and is regulated by various promoters and enhancers.
Sep 24, 2024 · This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein.
an additional marker of malignant potential of thyroid nodular lesions (oncofetal fibronectin) This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix.
Sep 16, 2021 · 1. Introduction. The extracellular matrix (ECM) is a substrate for cells that modulates migration, proliferation, differentiation, spreading and survival by serving as both a molecular reservoir and a structural scaffold with tissue-specific mechanical properties.
Jul 31, 2020 · Fibronectin 1 (FN1) is a glycoprotein molecule widely distributed in cell structures such as smooth muscle cell layer, vascular cell membrane and nerve cell layer. It participates in cell adhesion, migration and movement of various cells.
The FN1 gene encodes two types of fibronectin-1 protein, which are involved in blood clotting, wound healing, and extracellular matrix formation. Mutations in the FN1 gene can cause fibronectin glomerulopathy, a kidney disease that leads to end-stage renal failure.
