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Sodium channel blockers are drugs which impair the conduction of sodium ions (Na +) through sodium channels.
Sodium-channel blockers comprise the Class I antiarrhythmic compounds according to the Vaughan-Williams classification scheme. These drugs bind to and block fast sodium channels that are responsible for rapid depolarization (phase 0) of fast-response cardiac action potentials.
Apr 28, 2022 · Class I, sodium channel blockers: These drugs prevent sodium from getting through cell membranes. This can slow electrical impulses in the heart muscle. Examples include disopyramide, flecainide, mexiletine, propafenone and quinidine. Class II, beta blockers: These drugs
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Brittany Norton, MFA, Sam Gillespie, BSc, Yifan Xiao, MD. Antiarrhythmic drugs help control arrhythmias or abnormal heartbeats. There are four main groups of antiarrhythmic medications: class I, sodium-channel blockers; class II, beta-blockers; class III, potassium-channel blockers; class IV, calcium-channel blockers; and miscellaneous ...
Class I antidysrhythmic medications, also known as sodium channel blockers, are divided into three groups which differ by how they impact electrical conduction and repolarization.
Mar 27, 2023 · Sodium channel blockers help the heart's rhythm by slowing its ability to conduct electricity. Examples may include: Flecainide (Tambocor®) Propafenone (Rythmol®) Quinidine (Various) Potassium channel blockers help the heart’s rhythm by slowing down the electrical signals that cause AFib. Examples may include:
