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Due to their rapid metabolism, artemisinin and its derivatives are relatively safe drugs with a relatively high therapeutic index. History Etymology. Artemisinin is an antimalarial lactone derived from qinghao (青蒿, Artemisia annua or sweet wormwood).
Abstract. Artemisinins are derived from extracts of sweet wormwood ( Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis.
Oct 16, 2020 · Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by ...
Feb 1, 2019 · Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties.
Artemisinin, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.
Apr 24, 2022 · Artemisinin, one of the main constituents in the plant, is used in combination therapies for the treatment of malaria, and recent research indicates that it’s a useful tool for cancer treatment as well.
The 2015 Nobel Prize in Physiology or Medicine was awarded to Professor Youyou Tu for her key contributions to the discovery of artemisinin. Artemisinin has saved millions of lives and represents one of the significant contributions of China to global health.
Nov 18, 2022 · Artemisinin partial resistance typically refers to a delay in the clearance of malaria parasites from the bloodstream following treatment with an ACT. As a result, the artemisinin compound is less effective in clearing all parasites within a 3-day period among patients who are infected with artemisinin partial resistant strains of malaria.
Jun 6, 2023 · We now know that the unusual structural feature of artemisinin, the 1,2,4-trioxane ring, is the basis for the unique antimalarial action of the drug. It is the endoperoxide linkage in the ring which 'triggers' artemisinin to 'explode' - but only in the vicinity of the Plasmodium parasite.
Jul 1, 2023 · Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua. ART has a great therapeutic potential for treating human chronic diseases. Studies confirmed the effects in malaria, cancer, viral , bacterial infections and cardiovascular diseases.
