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Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls.
Dec 21, 2020 · Dihydropyridines are a type of calcium channel blocker (CCB), which refer to a group of medications that block calcium channels located in the muscle cells of the heart and arterial blood vessels, thereby reducing the entry of calcium ions into the cell.
May 15, 2024 · While all approved calcium channel blockers inhibit the L-type calcium channel on cells, they are divided into two major categories based upon their predominant physiologic effects: the dihydropyridines, which are predominantly vasodilators and generally have limited chronotropic and inotropic effects, and the non-dihydropyridines, which are ...
Jan 7, 2022 · Calcium channel blockers are a group of medications that limit how your body uses calcium. By slowing down how your cells use calcium, these medications can lower your blood pressure, prevent heart rhythm problems and more. Contents Overview Risks / Benefits Recovery and Outlook When To Call the Doctor.
May 31, 2024 · Choice of initial therapy in most patients— The three primary options for antihypertensive drug therapy in most patients include an ACE inhibitor (or ARB), a calcium channel blocker, or a thiazide diuretic (preferably a thiazide-like diuretic) [3].
Feb 22, 2024 · Objectives: Identify appropriate indications for calcium channel blockers in cardiovascular and non-cardiovascular conditions. Implement evidence-based dosing strategies and monitoring protocols for patients prescribed calcium channel blockers.
Jul 5, 2012 · Calcium-channel blockers (CCBs), comprise three distinct subgroups: benzothiazepines (e.g. diltiazem), dihydropyridines (e.g. amlodipine, nifedipine) and phenylalkylamines (e.g. verapamil). Despite this diversity, they are often referred to as a single, homogeneous class of pharmacological agents.
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