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  1. Nov 1, 2023 · Calcium channel blockers (CCBs) are split into two categories, dihydropyridines (DHP), such as amlodipine and nicardipine, and non-dihydropyridines (non-DHP), such as verapamil and diltiazem. While these two drug classes are both CCBs, there are some key similarities and differences that are important to take into consideration when prescribing ...

  2. Nondihydropyridine vs. Dihydropyridine Calcium Channel Blockers. Dihydropyridine: Think Amlodipine and Nifedipine (-dipine) They act through systemic vascular vasodilation of arteries. Can be used to treat angina.

  3. Jan 28, 2024 · Key Differences. Dihydropyridines, a group of medications, primarily act on vascular smooth muscles, causing vasodilation and reducing blood pressure. Nondihydropyridines, another group within the calcium channel blockers, have a more significant effect on the heart muscle, affecting heart rate and contraction strength. 8.

  4. Nov 18, 2012 · Summary: DHP and non-DHP drugs are used to treat high blood pressure. While they utilize the same basic process of vasodilation, they have additional mechanisms which may make them appropriate for certain conditions. The positive, inotropic effects of DHP drugs make them ideal for patients with cardiovascular conditions.

  5. Dec 21, 2020 · Dihydropyridines are a type of calcium channel blocker (CCB), which refer to a group of medications that block calcium channels located in the muscle cells of the heart and arterial blood vessels, thereby reducing the entry of calcium ions into the cell.

  6. It is generally accepted that nifedipine and nicardipine, dihydropyridine (DHP) calcium antagonists (Ca-antagonists), are less cardiodepressant that verapamil and diltiazem, non-dihydropyridine (non-DHP) Ca-antagonists, in therapeutic doses used in the treatment of angina pectoris and/or hypertension.

  7. Feb 22, 2024 · Dihydropyridine drugs are used to treat hypertension, coronary artery disease, and chronic stable angina. Non-dihydropyridine drugs are used to treat hypertension, paroxysmal supraventricular tachycardia (PSVT) conversion, PSVT prophylaxis, atrial fibrillation/flutter, chronic stable angina, and vasospastic angina.