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Nov 18, 2022 · Artemisinin partial resistance is seen as delayed parasites clearance after treatment with a drug containing artemisinin. In vitro and in vivo studies have shown that mutations in the PfKelch13 BTB/POZ and propeller domain ( PfK13 ) are associated with this delayed parasite clearance.
- Artemisinin resistance and artemisinin-based combination therapy ...
Artemisinin resistance is defined as delayed parasite...
- Artemisinin resistance and artemisinin-based combination therapy ...
Mar 28, 2022 · The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted...
Aug 23, 2023 · Partial resistance of Plasmodium falciparum to the artemisinin component of artemisinin-based combination therapies, the most important malaria drugs, emerged in Southeast Asia and now...
Sep 23, 2022 · While the world is aiming to eliminate malaria, artemisinin resistance threatens this objective. This review aims to describe the pharmacological properties of ACTs, the mechanism of artemisinin resistance and the potential changes needed in the treatment regimens to fight resistance.
Sep 22, 2021 · Abstract. Background. In the six Southeast Asian countries that make up the Greater Mekong Subregion, Plasmodium falciparum has developed resistance to derivatives of artemisinin, the main...
Artemisinin-based combination therapies (ACTs) have substantially reduced worldwide malaria burden and deaths. But malaria parasites have become resistant to artemisinins. Prior studies suggested two different molecular pathways of artemisinin-resistance.
Artemisinin resistance is defined as delayed parasite clearance following treatment with an artesunate monotherapy or ACT. This represents partial resistance. Artemisinin resistance alone does not necessarily lead to treatment failure.
