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  1. Nov 3, 2020 · Anion Gap = Na+ – (Cl- + HCO3-) The Anion Gap (AG) is a derived variable primarily used for the evaluation of metabolic acidosis to determine the presence of unmeasured anions. The normal anion gap depends on serum phosphate and serum albumin concentrations.

  2. Aug 7, 2023 · High anion gap metabolic acidosis (HAGMA) is a type of metabolic acidosis. Differentiation of acidosis into a particular subtype, whether high anion gap metabolic acidosis or non-anion gap metabolic acidosis aids in the determination of the etiology and hence appropriate treatment.

  3. Sep 12, 2017 · There are two main categories of metabolic acidosis: high anion gap metabolic acidosis (HAGMA) and normal anion gap metabolic acidosis (NAGMA). A HAGMA is illustrated in Figure 3b. Common causes of HAGMA and NAGMA are detailed in Table 2.

  4. Jul 1, 2024 · NAGMA fundamentally represents an imbalance between sodium chloride and sodium bicarbonate. Treatment therefore may involve addition of sodium bicarbonate and/or removal of sodium chloride. The optimal approach depends on volume status, for example:

  5. Aug 13, 2021 · The anion gap (AG) is a mathematical construct that compares the blood sodium concentration with the sum of the chloride and bicarbonate concentrations. It is a helpful calculation that divides the metabolic acidoses into 2 categories: high AG metabolic acidosis (HAGMA) and hyperchloremic metabolic acidosis—and thereby delimits the potential ...

  6. Jun 5, 2024 · Internal Medicine Journal. Review. Open Access. Demystifying normal-anion-gap metabolic acidosis: pathophysiology, aetiology, evaluation and diagnosis. Ritesh Bhandari, Adel Ekladious, Muhammad M. Javaid. First published: 05 June 2024. https://doi.org/10.1111/imj.16418. Funding: None. Conflict of interest: None. Sections. PDF. Tools. Abstract.

  7. Key points. •. Metabolic acidosis arises as a consequence of (i) an increase in endogenous acid, (ii) infusion or ingestion of an exogenous acid and (iii) an increased chloride concentration relative to sodium concentration. •.