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Oct 13, 2020 · ABSTRACT. Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both.
Oct 13, 2020 · Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both.
Aug 30, 2020 · Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.
The pathophysiology of diabetes involves plasm concentrations of glucose signaling the central nervous system to mobilize energy reserves. It is based on cerebral blood flow and tissue integrity, arterial plasma glucose, the speed that plasma glucose concentrations fall, and other available metabolic fuels.
Dec 1, 2002 · Diabetes mellitus is heterogeneous group of disorders, connected by raised plasma glucose concentration and disturbance of glucose metabolism. Glucose is under-utilised with resulting hyperglycaemia. It is necessary to say that, in most cases, the real aetiology is still clouded.
Spectrum of glucose homeostasis and diabetes mellitus (DM). The spectrum from normal glucose tolerance to diabetes in type 1 DM, type 2 DM, specific types of diabetes, and gestational DM is shown from left to right.
May 4, 2022 · Cluster-based phenotypic analyses demonstrate a higher frequency of severe insulin-deficient diabetes mellitus and demonstrate generally younger ages at diagnosis, lower β-cell function, lower...
Feb 1, 2022 · Abstract. Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the combination of genetic and environmental factors, and obesity, lifestyle, and aging are the most relevant risk factors. Hyperglycemia is the main metabolic feature of T2D as a consequence of insulin resistance and β-cell dysfunction.
Sep 1, 2023 · The pathophysiology of diabetes is largely based on insulin resistance, and many research studies have examined the factors such as environmental and genetic factors that promotetype 2 diabetes mellitus (Fig. 7) [26].
Key Points |. More Information. Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. Early symptoms are related to hyperglycemia and include polydipsia, polyphagia, polyuria, and blurred vision.
