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Objective. This article summaries the role of emerging novel therapies in the treatment of H. pylori. Known as sequential therapy and salvage therapy, these new therapeutic strategies are thought to produce eradication rates superior to currently recommended first-line therapies.
Jul 24, 2014 · Therapy for H pylori infection has undergone major changes, based on application of the principles of antimicrobial stewardship and increased availability of susceptibility testing. Common initial...
Oct 5, 2023 · The treatment regimen that is selected must consider local antibiotic resistance patterns (if known), previous exposure and allergies to specific antibiotics, cost, side effects, and ease of administration. This topic will review treatment regimens for H. pylori.
Whenever H. pylori infection is identified and treated, testing to prove eradication should be performed using a urea breath test, fecal antigen test or biopsy-based testing at least 4 weeks after the completion of antibiotic therapy and after PPI therapy has been withheld for 1 – 2 weeks.
Jan 15, 2018 · RECOMMENDED. Clarithromycin triple therapy consists of a PPI, clarithromycin (Biaxin), and amoxicillin or metronidazole (Flagyl) for 14 days. The effect of H. pylori resistance to...
In susceptible infected hosts, long-standing active chronic gastritis may result in gastric mucosal atrophy with intestinal metaplasia. In a minority, these premalignant mucosal changes progress to dysplasia and clinically silent, early cancer, followed by advanced gastric cancer.
Jul 17, 2020 · H. pylori infection is implicated in the pathogenesis of gastritis, gastric and duodenal ulcers, gastric cancer, and gastric mucosa‑associated lymphoid tissue (MALT) lymphoma [9 – 12]; its eradication is recommended in the treatment and/or prevention of these conditions [13, 14].
Sep 17, 2012 · The recommended duration of therapy for H. pylori eradication ranges from 7 to 14 days. The most widely recommended regimens are summarized in Table 1. Table 1. Regimens for Helicobacter pylori therapy. Open in a separate window.
Mar 3, 2021 · Bismuth quadruple therapy showed pooled eradication rate of 75.5% (95% CI, 71.6% to 79.1%) in the meta-analysis of the nine studies (Fig. 8). Regarding the treatment duration, four studies treated for 7 days, two for 10 days, and three for 14 days.
Aims of treatment. Treatment aims to eradicate H. pylori, reduce the risk of peptic ulcer disease, ulcer bleeding and gastric malignancy, and the recurrence of gastritis and peptic ulcers. Testing for Helicobacter pylori. The presence of H. pylori should be confirmed before starting eradication treatment ('test and treat' strategy).
